通过CellStyle设置

<DataGridTextColumn Header="ScreenName" Binding="{Binding ScreenName}" >
    <DataGridTextColumn.CellStyle>
        <Style TargetType="DataGridCell">
            <Setter Property="ToolTip" Value="{Binding Name}" />
        </Style>
    </DataGridTextColumn.CellStyle>
</DataGridTextColumn>

  

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