http://www.codeproject.com/KB/aspnet/DisableSubmitButton.aspx
public class WebForm1 : System.Web.UI.Page
{
protected System.Web.UI.WebControls.Button Button1;
private void Page_Load(object sender, System.EventArgs e)
{
}
#region Web Form Designer generated code
override protected void OnInit(EventArgs e)
{
Button1.Attributes.Add("onclick","javascript:" +
Button1.ClientID + ".disabled=true;" +
this.GetPostBackEventReference(Button1));
InitializeComponent();
base.OnInit(e);
}
/// <summary>
    /// Required method for Designer support - do not modify
    /// the contents of this method with the code editor.
    /// </summary>
    private void InitializeComponent()
{
this.Button1.Click +=
new System.EventHandler(this.Button1_Click);
this.Load += new System.EventHandler(this.Page_Load);
}
#endregion
private void Button1_Click(object sender, System.EventArgs e)
{
System.Threading.Thread.Sleep(5000);
//Response.Redirect("http://www.msn.com");
    }
}

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