E/AndroidRuntime: FATAL EXCEPTION: main Process: com.***.plants, PID: 23100
java.lang.RuntimeException: Unable to instantiate application com.***.MyApplication: java.lang.ClassNotFoundException: Didn't find class "com.****.MyApplication" on path: DexPathList[[zip file "/data/app/com.****.plants-1/base.apk"],nativeLibraryDirectories=[/data/app/com.***.plants-1/lib/arm64, /system/fake-libs64, /data/app/com.***.plants-1/base.apk!/lib/arm64-v8a, /system/lib64, /vendor/lib64]]
at android.app.LoadedApk.makeApplication(LoadedApk.java:853)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:5681)
***
Caused by: java.lang.ClassNotFoundException: Didn't find class "com.***.MyApplication" on path: DexPathList[[zip file "/data/app/com.****.plants-1/base.apk"],nativeLibraryDirectories=[/data/app/com.***.plants-1/lib/arm64, /system/fake-libs64, /data/app/com.***.plants-1/base.apk!/lib/arm64-v8a, /system/lib64, /vendor/lib64]]
***
解决方法：
打开设置：file->settings，搜索Instant Run，取消勾选Enable?Instant Run to***如图：
关于Instant Run：是Android Studio2.0之后更新的一个强大的功能！在第一次运行之后，修改后的代码UI等不需要再build！可以快速再在真机上看到效果！节约生命