var tableA = new DataTable();
tableA.Columns.Add("Currency", typeof(string));
tableA.Columns.Add("Rate1", typeof(decimal));
tableA.Columns.Add("Rate2", typeof(decimal));
tableA.Columns.Add("Rate3", typeof(decimal));
tableA.Columns.Add("Rate4", typeof(decimal));
tableA.Columns.Add("Rate5", typeof(decimal));
tableA.Columns.Add("Rate6", typeof(decimal));
tableA.Rows.Add("USD", 1m, 2m, 3m, 4m, 5.5m, 4.5m);
tableA.Rows.Add("JPY", 1.11m, 4.1m, 3.3m, 4.6m, 5.5m, 3.3m);
tableA.Rows.Add("GBP", 3.0m, 1m, 3m, 4m, 7.7m, 8.8m);
tableA.Rows.Add("EUR", 3.0m, 1m, 3m, 4m, 7.7m, 8.8m);
tableA.Rows.Add("MXN", 3.0m, 1m, 3m, 4m, 7.7m, 8.8m);
var tableB = new DataTable();
tableB.Columns.Add("Currency", typeof(string));
tableB.Columns.Add("Rate1", typeof(decimal));
tableB.Columns.Add("Rate2", typeof(decimal));
tableB.Columns.Add("Rate3", typeof(decimal));
tableB.Columns.Add("Rate4", typeof(decimal));
tableB.Rows.Add("USD", 1m, 2m, 3m, 4m);
tableB.Rows.Add("JPY", 1.11m, 9.9m, 3.3m, 4.6m);
tableB.Rows.Add("GBP", 3m, 1m, 3m, 4m);
var query = from r1 in tableA.AsEnumerable()
from r2 in tableB.AsEnumerable()
where
r1.Field<string>("Currency") == r2.Field<string>("Currency")
&& r1.Field<decimal>("Rate1") == r2.Field<decimal>("Rate1")
&& r1.Field<decimal>("Rate2") == r2.Field<decimal>("Rate2")
&& r1.Field<decimal>("Rate3") == r2.Field<decimal>("Rate3")
&& r1.Field<decimal>("Rate4") == r2.Field<decimal>("Rate4")
select r2;
var result = tableB.AsEnumerable().Except(query).ToList();